I greatly enjoy this game, but my wrists do not. If you can find a way to implement interreacting with characters without using a mouse I believe many users including myself would appreciate this. Perhaps when close to an interactable, we can press "e"? I think the best option is to make a way to configure the controls anyway one would need. Like in a settings menu. I do greatly appreciate the fully-usable with mouse aspect. younger me would of liked that a lot. Alas, my hands aren't as dexterous as they used to be.
With that out of the way, your pixel art style is beautiful. You're a master of colors and using negative space to your advantage.