this isn't the correct way to fullscreen the game go to options instead and turn off fullscreen fetish that other menu doesn't work for this game since its overridden
This has affected the game for ages though and has been addressed.
Game Page:
FAQs about errors and suggested fixes.
Q: Game’s screen is stuck in 640x480 resolution? No sounds are playing? No BGM is playing? A: Please reset _ResetRMsetting.reg , then run the game again.
The RPGMaker fullscreen option in the F1 settings applies to ALL RPGM games [in this case specifically, all RPG Maker VX Ace games], not just the currently launched game. (Hence why the default F1 hotkey is blocked)