For the gender settings, you could toggle the gender distribution panel on the world generation options right at the beginning of the game after you 'agreed' to the terms and conditions(?) of the game! You'll need to move the 'male' Slider towards the left if you want 0 male in your save!
And yeah, if there's some kind of siblings mechanism it'll surely be much more exciting to the gameplay XD
you can't truly get like 0 men in your run, if i remember correctly. you'd have to turn off traditional club members so that you wouldn't encounter male football players. in the world generation settings there's also like an option at the bottom to customize the gender of special npcs (the 360 guy, the librarian, everyone with a special role basically like the owners of the river rat and quickieburger and many more.)
