Overall a fairly unique rhythm game concept that we don't often see in this unit, sounds cool. Because this style of game is a long way from the type of games our tutorials cover, you'll need to research early on the feasibility of this type of game. In general it shouldn't be too difficult, but like you'll need to leverage coroutines at least to time the notes etc.
An added complexity that a rhythm game normally doesn't have to worry about is that you still do have an AI character that you'll need to code up as well.