Won't start and then it doesn't respond at all
Does it try to open at all, have you unzipped the file? I know when you run it via the renpy launcher it will verify it and then you might need to allow it to run from your system preferences/ system and security.
consider downloading a different unzipper, like the unarchiver, it worked for me
Please do try with this new 1.6.1 version (as I did fix a couple of issues that could help MAC users!)