The two issues are linked. Okay so the second agility rune is close to the first, it's inside the clinic, on the eye chart. Pretty sure you can't miss the first but if you did it's just outside on on the wall.
Amy will help you get passed the wolves after some progress. If I'm remembering clearly I think you need to talk to Bianca first. If you still need help, let me know.
If you are talking about the symbol outside with the goth girl on the wall I see it but it doesn't light up when I put the scanner or don't remember the name usually they light up for example the one on the bench in the garden but this on the wall outside it didn't light up this is the only symbol left that I found nothing else