it is with the game you download or the game you get through the .zip?
I have no idea to be honest. Ren'py lets you just make a mac version, and that's what I've uploaded. I truly have no idea how games work on mac, but I assume there's some way since the mac version has been downloaded thousands of times, so I'd assume that if it didn't work I'd probably get more comments about this. Do you have any issues running other AVNs on your machine? It should work basically the same as any ren'py based game.