Every run where I've survived has eventually crashed a few minutes after the first mini-boss. I'm guessing this is ~15 min of gameplay.
Yes, for the crash log I posted, I noticed the tile in the upper left was "blank", i.e. no textures/ruins/trees.
Chrome: Version 127.0.6533.120 (Official Build) (x86_64)
Mac OS X: 14.3.1 (23D60)
Hope this helps!