The Apple Silicon version won't open on Macos, NOT due to an issue with having to go into settings and manually allow the app, but for some unknown reason that's currently beyond me.
If it helps, I have an M5 Macbook Pro.

Create and customize Wii U injects from your own game backups. · By
Do you know that it's not opening, or when you launch it, you aren't seeing it appear? If you're unsure, open up Activity Monitor and see if it's in there. I'm using an M2 Mac Mini and I'm able to unzip the file, drag the app into Applications and launch it from there. Let me know with any updates that you have please.