This game is real great, but holy heck it took a while to learn. It took me 3+ hours across multiple months to figure out what to even do to win, and then doing it was still somewhat difficult. As such, here's a guide with various important things *I* learned while playing!
THIS WILL SPOIL SOME THINGS! IF YOU WANT THE EXPERIENCE OF DISCOVERING SOLUTIONS ON YOUR OWN, PLAY THE GAME BLIND FIRST
The main goal of the game is to remove all deadlocked clothes- and you start the game with one (your control suit). To do this, you need to get three deadlock key pieces from Jean (the woman in your house, to the left of the starting area). After you complete a run, the first key piece you buy is 100c. The second one is 400c, then 700, etc. If you do another run, I believe the values reset to 100c. So, it is usually in your best interest to purchase one key piece, do a run, purchase one key piece, do a run, etc.
You can get MORE deadlocked clothes by either taking too long on a floor (spawning a stalker character that will slowly approach, & force deadlocked clothes onto you), or by freeing some trapped slaves in the world. Unfortunately, this essentially doubles your game time, since you need to get ANOTHER deadlock key. So, it's best to avoid these if you want to be efficient. :<
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Alternatively, there's two other endings you can go for- maid, or pony. As far as I know, you can only ever get one per save file- once you choose either the maid or pony job, there is no going back and you cannot switch jobs. (there might be one more secret ending? I never got lucky enough with item spawns though, so I'm omitting instructions here for now in case my understanding is flawed. If someone else has intel, please leave it somewhere)
The pony job has you bringing boxes to the escape ladders on some floors. Meanwhile, the maid job has you cleaning detritus areas, which lock you into a bullet-hell minigame where you dodge spikes and grab brooms.
Once you collect all the clothes in the maid set or the pony set, you can find a permalocker (a tall-ish structure on some floors) and lock yourself in to get the ending.
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To discuss the game mechanics of bondage- each bind you get has different affects, and different ways to escape. Some need key pickups to be unlocked, some need control keys, some need nothing at all, etc. Trying to take one off will trigger a minigame depending on the clothing type. Win the minigame, and it'll be removed from your person and put in your inventory!
Alternatively, you can take them off with Robo Claws in the world. As far as I know, they remove one random piece of binding. They can seemingly remove anything, except for deadlocked stuff (obviously).
Semi-unrelated, but you can click on your inventory to put on any clothes you've gotten so far. You WILL need to do the minigame again to remove them, but it's a small price to pay for fashion.
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One extraneous tip- combat seem preeeeety useless as far as I know. I could never figure out how to power up my slaps...? And anyway it seems more efficient to just run past.
Hope this helped someone out there <3