This is a spoiler free guide on how to get the most amount of content without missing much of what the game can offer.

1. The beggining of the game:

To begin, it's recommended that you buy neccessary items right away, try to use the limited money you have to buy bandages and Dr Dynamites, these items are super helpful anywhere in the game and will help you survive long adventures and though fights.

2. Story Encounters:

During the story you will find and face unique characters, who will propose several challanges to you, but at the end of these challanges. I inmesnly recomed to be MERCIFUL with these characters as they are fundamental later on, if you aren't  merciful with them it WILL come back to bite you, with that said, you are free to do what you want.

3.  Last stretch.

At the last stretch of your adventure, the main path may become a bit confusing. To begin head to the upper left corner spot of the map in order to continue the adventure. Check the place out and equip yourself with anything you need. If you wish to continue with the story head up in that city, althought it is recommended that you look around first.

After doing so you are encourage to explore other places, as it can be really rewarding and beyond useful.