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to be fair before i didn't like any game that use multiple assets i feel like the developers are lazy and just want quick money like Synty Studio it is common to see developers use their assets there for they appear in many games.

but now since I'm a developer this save me a lot of time(witch i don't have a lot of) and effort(I'm not a 3d modeler and don't know how to use 3d Model software).

I want to know how this effect my game. Example" Someone see my game but don't want to play/download/purchase the game cause I'm using other assets i found on the store.

Another option is to look for assets from people here on itch or other places where you can download stuff directly from creators. It only involves a little extra work (i.e. importing the assets into your project manually instead of letting the store do it for you) and you will be able to find more unique works. You'll also be supporting indie artists by hopefully crediting them and/or paying. 

I do that all the time also Unity make it easy to import assets from outside the store however when purchase from the unity assets store you gain a license for using the asset does Itch.io have something similar?

Yes, but it is up to the uploader to write the license terms, usually included with the download in license.txt or similar