Have you tried Excessive Cum and Intense Orgasm, and only those two?
Minoh Workshop
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They're all based on Greek lyres, though heavily modified from the standard design.
The left one is a chelys-style barbiton. It's by no means a traditional chelys, but still it's chelys-style.
The right one is inspired on the U-shaped lyre from Hagia Triada Sarcophagus while mixing it with the Minoan symbol we call the "horns of consecration." I don't know how I'd classify it, but perhaps the closest would be calling it kithara-style (though not with the movable crossbar that Luthieros has on their kithara model).
Sorry for taking a while, I was busy with irl stuff.
In short, some mythicals originate from humans being modified to be more animal-like, and some were animals modified to be more human-like.
P and Argos, for example, both originate from lineages of humans who were transformed. As such they can still have kids if they pair up with humans, and sometimes the "mythical gene" can skip a generation.
Meanwhile Themba and the grootslangs do not descend from humans in any way, so they can't have kids with humans.
That's what I meant for the longer answer.
The Hotel's rules (through the contracts the masters signed over the centuries) are a mess of makeshift things piled up on top of each other. When it comes to this point in particular, previous masters made it so that most (but not all) life could not reproduce above the cliff wall. That's why, very specifically and since the first build, we make a point of saying that there was no fungi/mold in the hotel when the player arrived. This doesn't affect beneficial gut bacteria, FYI.
That is to say, if someone has an infection when they reach the hotel it'll stop multiplying in them and recede. Some conditions may be cured by this, while others would only go into remission.
If you're using Android, just install the .apk and run the app.
If on Windows or Mac, unpack the .zip files and run the executable. If you're using Mac you might have to mess around with the security settings to allow the game to run.
Or you can install the Itch.io app and it should handle all of this for you.