I absolutely adored this game! It really makes you feel like Sherlock Holmes or Dr. House (which lets be honest, it's the same character). And I'm loving the win95 aesthetic... though a right-click menu on the email messages to speed up deletion would be greatly appreciated (without having to open up the emails first), as well as an auto select of the next email when deleting the one currently selected.
Also, some buttons (such as the "Got it" in the popups) have very small clicking areas and can be easy to miss.
Oh, and some elements desapear when going fullscreen (like the help guy and the notifications); they are probably getting misplaced when screen size changes.
Prescription: keep up the good work!
Diagnosis: 10/10 great game concept and great execution :^)