Hi, thanks for looking into my game! As for your questions, creating animations and sprites can be done with any image editor (I used an online editor called piskel). In order to integrate these graphics into Unity, which is the program o used to make this game, I recommend you look at some tutorials on sprites and animations in Unity.
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Congrats, herculesking! You gave me my first comment! Thanks! Anyways, I have posted the Unity Project file (called "2D Roguelike.zip") on the game page. Take a look at the Player (Player.cs) script in the file. That is where you will find the code (with comments) for the player attacking enemies. If you have any other questions, feel free to shoot me an email at email@example.com (just make sure to say that you're from itch.io, or else I may mistake it for spam!).