Starts game.
Checkboxes for acceptable kinks.
Checks NTR.
There is No NTR!
Checks NTR Again.
Are you Dense? THERE IS NO NTR!
Plays game.
dadadada.
There's NTR
If you want to do a quick and dirty solution, write a launcher to configure things like image cache sizes and various other settings. Some quick configuration tweaks and suggestions given detected hardware resources should provide an adequate performance boost. Reading O'Reilly's High Performance Python couldn't hurt, and there are some Ren'py performance guides too. When in doubt check out what the Eternum Dev is doing.