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As far as I can tell,  it affects almost every Ren'Py game I download through the Itch app.  Something about the permissions not being set properly because of translocation on Macs.

it looks like this may be the issue: https://github.com/itchio/itch/issues/2223

i think this might be able to be fixed if you play games without sandbox mode, but i wouldn't recommend that unless you are sure that a game is safe to use.