you mean initial (opponent) hit? Yes, sure, but I'm talking about 3d turn (opponent) fully charged hit. After those toys\potions\libido dust\ultimate ability implementations it can easily be 500k damage.
upd: I mean yes, technically you can make one-shot on 2d turn if your opponent not invested in HP , but its even more random. Example: my set do initial hit from 11k-34k, that's a huge difference!