I'm having some trouble with level 4 difficulty. The closest I've been so far it's final boss against Voss, losing here. I even had double moonbeam on Karakai, but it was not enough. Damn XD
It's hard. I'll try again. I can't imagine the level 5! I'm not a hardcore roguelike gamer, but I humbly think I'm good enough with them (beaten all of Slay the Spire before and games as that).
I'll try harder!