Certainly!  I have a triple monitor setup and I run it along a full screen video on the second screen. If I run it with no other full screen apps running at the same time it seems to be running better but still not very smooth. 

OS: Manjaro 18.0.0-rc Illyria
    Kernel: x86_64 Linux 4.19.0-2-MANJARO
    Uptime: 25m
   Packages: 1223
   Shell: bash 4.4.23
    Resolution: 5120x1080
    DE: KDE 5.51.0 / Plasma 5.14.2
   WM: KWin
      WM Theme: Breeze
    GTK Theme: Breeze [GTK2/3]
   Icon Theme: breeze
   Font: Noto Sans Regular
  CPU: Intel Core i7-3770K @ 8x 3.9GHz [45.0°C]
GPU: GeForce GTX 970
  RAM: 2433MiB / 15980MiB