Beautifully done - an interesting and fresh take on Snake, that becomes surprisingly devious with its puzzles, is presented intuitively, drawn and animated wonderfully and makes great use of the resolution restriction. It controls as well as you could ever hope for a game like this to - it's the whole package.
All I have to say that's negative are the smallest nitpicks - I wish the snake's tail moving was a bit more immediate, I sometimes had to pause to see if I'd left myself enough room, thinking I hadn't, but then the tail moved. I also kept wanting the song to transition into Another One Bites the Dust.
That's all I have negative to say against this otherwise incredible entry!