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No.  It would be too tricky to code.  I get what you're saying though - I've fallen victim to it myself on occasion.  That's when I have to remember to slow down, and look at what's highlighted.  If it's a frequent problem, you can use the keyboard instead - pg up/pg down to select the item and one of your activate keys (Enter or Keypad Enter by default) to use it (or 'd' to drop it).