I’m not sure it would work if it was used as the only multi-use mechanic, as that might be seen as kind of a copout, but I think it would be funny to acknowledge it as long as the game had an actual gameplay-related multi-use mechanic.  (But it would be awesome if you could somehow tie the two together—like a Legend of Zelda: Oracle of Ages / Oracle of Seasons type deal where each game can be played on its own, but they change into something else if you play them both.)